用植物化学物质向癌症干细胞:分子机制和治疗潜力
Ashok Kumar Sah1, Joy Das2, Abdulkhakov Ikhtiyor Umarovich3
1Department of Medical Laboratory Sciences, College of Applied and Health Sciences, A' Sharqiyah University, Ibra 400, Oman.
Biomedicines
|January 28, 2026
概括
植物化学物质,天然植物化合物,可以通过破坏驱动瘤生长和抵抗的途径来向癌症干细胞 (CSC). 纳米技术增强了它们的传递,提高了对抗癌症复发的有效性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 癌症干细胞 (CSCs) 驱动瘤生长,转移和治疗耐药性.
- 细胞内核细胞依赖于发育和炎症途径 (例如,Wnt,Notch,STAT3) 和上皮-介质细胞过渡 (EMT).
- 植物化学物质是具有多目标抗癌潜力的天然化合物.
研究的目的:
- 审查植物化学品在向癌症干细胞 (CSCs) 中的作用.
- 探索植物化学物质如何调节CSC自我更新,茎状途径和耐药性.
- 讨论基于纳米技术的传递系统,以提高对CSCs的植物化学疗效.
主要方法:
- 文献综述综合了关于特定植物化学物质 (黄素,硫黄素,白醇,EGCG,基因斯坦,奎尔塞丁,帕氏化物,柏柏林,维他费林A) 的发现.
- 对CSC标记物 (ALDH+,CD44+/CD24-),EMT和药物外流载体的植物化学作用的分析.
- 基于纳米技术的输送系统 (纳米粒子,脂质载体) 的评估,以提高植物化学物质的生物可用性和向性.
主要成果:
- 著名的植物化学物质抑制CSC自我更新,球体形成和EMT.
- 植物化学物质干扰关键的茎度调节器,并通过降低药物排放的调节来使CSC对化疗敏感.
- 基于纳米技术的传递系统改善了植物化学稳定性,瘤积累和CSC特定向,在临床前模型中增强了反CSC效应.
结论:
- 植物化学物质是癌症干细胞生物学的强大调节剂.
- 优化的输送策略,特别是纳米技术,对于提高植物化学疗效至关重要.
- 证据支持植物化学品和纳米配方用于组合疗法,以改善癌症治疗的临床结果.
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