一个整合性的路线图,以推进结肠直肠癌的器官
Youqing Zhu1, Ke He1, Zhi Shi1
1Cancer Minimally Invasive Therapies Centre, Guangdong Second Provincial General Hospital, Department of Cell Biology & Institute of Biomedicine, Guangdong Provincial Biotechnology & Engineering Technology Research Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Genomic Medicine Engineering Research Center of Ministry of Education, MOE Key Laboratory of Tumor Molecular Biology, National Engineering Research Center of Genetic Medicine, State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
来自患者的结直肠癌 (CRC) 器官为研究癌症提供了先进的模型. 未来的研究需要下一代平台和计算工具,以实现个性化治疗和临床翻译.
科学领域:
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
- 生物技术是生物技术.
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题.
- 来自患者的CRC有机体比2D模型更好地模仿初级瘤.
- 有机系统正在向复杂的共同培养和迷你殖民地模式发展.
研究的目的:
- 审查CRC有机体技术的进展.
- 确定CRC有机体研究的局限性和未来方向.
- 为下一代CRC有机平台和计算框架提出路线图.
主要方法:
- 使用患者衍生的结直肠癌 (CRC) 器官.
- 结合免疫器官共同培养和迷你结肠系统.
- 利用高通量技术,基于CRISPR的功能基因组学和多基因组学.
主要成果:
- 先进的有机体平台增强了对CRC机制和药物反应的研究.
- 目前的模型缺乏系统生理学和标准化,需要进一步开发.
- 下一代平台和人工智能驱动的方法承诺加速发现和个性化治疗.
结论:
- CRC有机体研究正在快速推进,将基础科学与临床应用联系起来.
- 未来的方向包括开发标准化,复杂的有机体系统和整合计算工具.
- 这些进展对于加速CRC研究,实现个性化医疗和改善临床结果至关重要.
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