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Updated: Jan 29, 2026

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在巴西南部葡萄种植中使用的曼科泽布的毒性:一个横截面研究
Sheila de Castro Cardoso Toniasso1, Camila Pereira Baldin1,2, Vittoria Calvi Sampaio1
1Graduate Program in Gastroenterology and Hepatology, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.
International journal of environmental research and public health
|January 28, 2026
概括
葡萄园工人接触曼科泽布真菌杀菌剂与氧化应激和DNA损伤有关. 一项新的研究提出了对乙烯尿素 (ETU) 的生物暴露限值,以保护工人的健康.
科学领域:
- 职业健康 职业健康 职业健康
- 环境毒理学环境毒理学
- 农业科学 农业科学
背景情况:
- 巴西南部的葡萄种植主要依赖于杀菌剂Mancozeb.
- 人们对曼科泽布暴露的慢性健康影响存在担忧,包括氧化应激和基因毒性.
研究的目的:
- 为了研究南巴西葡萄园工人暴露在Mancozeb的健康影响.
- 为了确定乙烯尿素 (ETU) 的生物暴露极限,这是一个关键的曼科泽布代谢物.
主要方法:
- 对94名参与者的横截面研究 (50名暴露的葡萄园工人,44名未暴露的有机农民).
- 收集人口,健康和职业数据;分析血液/尿液的生物标志物,基因毒性和尿液ETU.
- 使用彗星测定和微核测试进行基因毒性评估.
主要成果:
- 暴露于曼科泽布的工人显示氧化应激标志物显著增加 (p < 0.001).
- 在两项基因毒性测定中都观察到显著的DNA损伤 (p < 0.001).
- 发现尿液ETU水平升高,暴露的临界值为69.3 ng/mL.
结论:
- 提出了一种新的,针对尿液ETU度的特定生物暴露极限.
- 调查结果强调了对曼科泽布暴露的监管限制和预防策略的需要.
- 这项研究通过提供曼科泽布暴露的定量标记来推进职业健康.
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