使用格子博尔兹曼法在有孔介质中对牛顿式和非牛顿式流体的振动诱导运输的研究
Soon Wook Kwon1, Hee Min Lee1, Hyun Cheol Yeom2
1Division of Quantum Computing, Department of Mechanical Engineering, Yonsei University, Seoul 03722, Republic of Korea.
Bioengineering (Basel, Switzerland)
|January 28, 2026
概括
设备振动通过增强液体分散和耐受性来改善基于针的药物输送. 这项研究揭示了振动背后的流体力学,表明它减少了剪切应力并改善了药物吸收.
科学领域:
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
- 药物运输 药物运输 药物运输
背景情况:
- 基于针的药物输送面临着患者疼痛和药物吸收不一致的挑战.
- 设备级振动是改善药物分散和患者舒适性的有希望的策略.
- 振动辅助输送的基本流体机械原理尚未完全理解.
研究的目的:
- 在基于针的交付中研究器件水平振动的流体机械基础.
- 量化振动对诸如湿面积,分散和剪切应力等关键传递参数的影响.
- 建立振动参数与改善药物吸收条件之间的联系.
主要方法:
- 使用一个格子博尔茨曼模型与多孔介质皮肤替代品.
- 在不同幅度 (0%,16.6%,35.1%) 的时间周期输入压力应用于牛顿式和非牛顿式的流体配方.
- 在单个循环中量化墙壁剪切应力,受湿面积,分散长度和压力成本.
主要成果:
- 振动显著增加了正常化的受湿面积 (10.6%21.3%) 和先进的透/分散.
- 每个受湿区域的压力成本与振动 (3.9%7.80%) 相比下降.
- 对于剪切稀释液体,振动重塑了墙壁剪切历史,减少了持续的剪切暴露.
结论:
- 振动通过增加受湿面积和改善透率来增强药物分散和仓库形成.
- 振动减少了组织的持续剪切应力,可能提高了耐受性.
- 该研究建立了一种流体机械机制,用于振动辅助的药物输送,优化药物吸收的条件.
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