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抑郁症,止痛药的使用和骨关节炎的功能之间的联系:骨关节炎倡议队列的倾向得分匹配分析
Saran Singh Gill1, Gareth G Jones1, Justin P Cobb1
1MSk Lab, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0BZ, UK.
Bioengineering (Basel, Switzerland)
|January 28, 2026
概括
膝关节骨关节炎患者的抑郁症状并没有增加阿片类药物使用,但与身体健康状况不佳有关. 然而,这些患者往往比没有抑郁症状的患者表现出更大的功能增长.
科学领域:
- 整形外科 整形外科 整形外科
- 精神病学是一个精神病学.
- 数据科学数据科学数据科学
背景情况:
- 膝关节关节炎 (OA) 影响着相当一部分老年人.
- 超过25%的膝关节OA患者出现抑郁症状 (DSs),这些症状与更严重的疼痛和结果有关.
- DSs对止痛药的使用和膝关节OA的恢复的影响尚不清楚.
研究的目的:
- 调查DSs对膝盖骨关节炎患者的止痛药使用和功能恢复的影响.
- 为了比较膝关节OA患者与没有DSs之间的结果.
主要方法:
- 利用了来自骨关节炎倡议的数据 (n=3680).
- 采用机器学习梯度提升机器 (GBM) 模型进行倾向得分匹配.
- 将487名膝关节OA和DSs患者与487名膝关节OA没有DSs的患者匹配.
主要成果:
- 到第二年,DSs与阿片类药物使用增加无关 (OR=0.89).
- 患有DS的患者在第一年不太可能表现出SF-12 PCS的改善,并且在第二年更有可能出现下降.
- OA中的DS与身体健康状况较差有关,但与没有DS的患者相比,往往表现出更大的功能收益.
结论:
- 膝关节OA患者的抑郁症状不会显著改变阿片类药物的使用.
- 虽然DS与较差的身体健康结果有关,但它们可能不会阻碍功能收益.
- 解决疼痛和心理社会福祉的多学科方法对于管理膝盖骨关节炎患者至关重要.
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