会影响结构和材料的合,以及与年龄相关的牙膜关节生物力学和应变
Haochen Ci1,2,3, Xianling Zheng1, Bo Wang1,2
1State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116023, China.
Bioengineering (Basel, Switzerland)
|January 28, 2026
概括
硬或软的食物会随着时间的推移改变老鼠关节结构和材料特性. 饮食的硬度会影响dentoalveolar关节的刚性和骨,影响长期的关节健康.
科学领域:
- 生物力学 生物力学
- 生物材料科学 生物材料科学
- 发展生物学 发展生物学
背景情况:
- 了解主要结构特征和次要材料特性如何适应功能负载,对于确定它们对随时间变化的关节生物力学的影响至关重要.
- 牙膜关节 (DAJ) 对于非常重要,其长期健康受到饮食和衰老的影响.
研究的目的:
- 将主要结构特征的时空变化,次要材料属性和 DAJ 刚性与年龄进行映射和相关联.
- 调查加载历史 (软与硬食物饮食) 如何塑造DAJ中主要和次要特征之间的平衡.
主要方法:
- 从4周大开始,老鼠被食硬食品 (HF) 或软食品 (SF) 饮食,长达20周.
- 在多个时间点 (8,12,16,20和24周) 进行完整下DAJ的功能成像.
- 主要结构决定因素 (牙周带空间,接触区域,形) 和次要材料/微观结构决定因素 (组织水平的硬度,骨/水泥体积分数,孔隙结构,骨微观结构) 的量化.
主要成果:
- 骨和体体积分数在HF和SF组不同增长,与PDL空间减少相关.
- 较老的HF大鼠比SF大鼠保持更宽的PDL空间;SF组与年龄相比接触率增加.
- 在SF中,DAJ刚度比年轻的HF动物高,这表明饮食依赖的重塑改变了结构与物质的贡献.
- 骨应变 (体积和·米塞斯) 在两组中随着年龄的增长而增加,SF骨表现出更高和更可变的应变值.
- 关节空间,接触区域和骨应变与DAJ生物力学相关.
结论:
- 主要 (结构) 和次要 (材料性质,微观架构) 特征的时空变化为DAJ定义了不同的机械生物学途径.
- 改变的加载历史可以使DAJ偏向早期的不适应和潜在的退化.
- 饮食硬度显著影响DAJ的发育,适应和长期生物机械功能.
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