预测膝关节骨关节炎的长期疼痛抵抗力:一个骨关节炎倡议的诺莫格拉姆
Ahmad Alkhatatbeh1, Tariq Alkhatatbeh2,3,4, Jiechen Chen1
1Department of Orthopedics Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Bioengineering (Basel, Switzerland)
|January 28, 2026
概括
一个新的临床名谱预测膝关节骨关节炎患者的长期疼痛恶化. 这种工具有助于估计持续疼痛的可能性,有助于对放射性膝关节关节炎的预后咨询.
科学领域:
- 整形外科 整形外科 整形外科
- 类风湿病学 类风湿病学
- 临床流行病学临床流行病学
背景情况:
- 目前膝关节骨关节炎的预后工具通常依赖于成像或生物标志物.
- 这些方法在临床环境中并不总是常规可用.
- 需要可访问的工具来预测长期疼痛轨迹.
研究的目的:
- 开发和验证一个临床的nomogram预测长期的疼痛不适应性在患有放射性膝关节关节炎的个体.
- 为了估计临床重要疼痛恶化在4年期间的概率.
- 为预后咨询和风险分层提供一个工具.
主要方法:
- 利用了骨关节炎倡议的数据,包括患有膝关节骨关节炎的参与者和完整的WOMAC疼痛评分.
- 定义非性为在4年内WOMAC疼痛量表上增加≥9个点.
- 开发了一个六个预测因素的Firth逻辑回归模型 (年龄,BMI,Kellgren-Lawrence等级,基线疼痛,0-24个月疼痛变化,CES-D得分) 并将其转化为名ogram.
主要成果:
- 在2365名符合条件的个人中,确定了527名 (22.3%) 非弹性参与者.
- 该模型表现出良好的性能,乐观度校正的AUC为0.74和Brier评分为0.15.
- 早期疼痛恶化和较高的抑郁症状被确定为非弹性最强的预测因素.
结论:
- 开发的六变量名图是临床准备好的,简单的,精心校准的工具,用于膝盖放射性关节炎的预后咨询.
- 它通过估计长期疼痛不可抗性的概率,有助于风险分层.
- 在广泛临床实施之前,建议进行外部验证.
相关概念视频
Initiation of Translation
38.9K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
38.9K
Initiation of Translation
8.1K
8.1K
Knee Joint
3.2K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
3.2K
Long-term Depression
33.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Dosage Regimen Designs: Nomograms and Tabulations
193
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
193
Predicting Molecular Geometry
45.7K
VSEPR Theory for Determination of Electron Pair Geometries
45.7K


