酸食补充剂通过激活子的Nrf2信号来缓解热应激诱导的肠道氧化损伤
Jiali Chen1, Rongmei Ji1, Fuchang Li1
1Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, Department of Animal Science and Technology, Shandong Agricultural University, Panhe Street 7, Tai'an 271017, China.
Antioxidants (Basel, Switzerland)
|January 28, 2026
概括
酸 (CGA) 通过减少肠道氧化损伤和通过Nrf2信号改善肠道屏障功能来保护子免受热应激. 这为子产业提供了一个可持续的营养策略.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 分子生物学分子生物学
背景情况:
- 热应激 (HS) 通过引起肠道氧化损伤,对子的健康和生产力产生负面影响.
- 酸 (CGA),一种天然的多,表现出抗氧化特性.
- 了解CGA对HS引起的肠损伤的保护机制对于子行业至关重要.
研究的目的:
- 为了研究CGA对子热应激诱导的肠损伤的保护作用.
- 阐明潜在的分子机制,特别是Nrf2信号传递的作用.
主要方法:
- 在HS挑战的子体内研究测量了血清抗氧化酶活性 (CAT,SOD),氧化应激标志物 (MDA) 和HSP70水平.
- 对抗氧化剂 (HO-1,SOD1) 和与亡相关的基因 (Bax,caspase-3) 的基因表达分析.
- 使用肠上皮细胞进行体外研究,以评估亡,ROS产生,紧结蛋白表达 (occludin,ZO-1) 和Nrf2通路激活.
主要成果:
- 在HS子中,CGA显著增加了血清CAT和SOD活动,并降低了MDA和骨HSP70水平.
- CGA逆转了HS诱导的抗氧化剂和亡相关基因表达的变化.
- 在体外,CGA降低了亡和ROS,保留了紧结蛋白,并激活了Nrf2信号,这对于这些保护作用至关重要.
结论:
- 在子中,CGA有效地减轻热应激诱导的肠道氧化损伤,并保持肠道屏障的完整性.
- 保护机制涉及Nrf2信号通路的激活.
- CGA提供了一个有希望的,安全的营养干预措施,以提高子的耐热应激和生产力,支持行业的可持续性.
相关概念视频
Responses to Heat and Cold Stress
14.7K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.7K
Dietary Connections
61.7K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
61.7K
Nitric Oxide Signaling Pathway
6.3K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.3K
Alkynes to Carboxylic Acids: Oxidative Cleavage
6.8K
Alkynes undergo oxidative cleavage in the presence of oxidizing reagents like potassium permanganate and ozone. The triple bond — one σ bond and two π bonds — is completely cleaved, and the alkyne is oxidized to carboxylic acids. When warm and basic aqueous potassium permanganate is used as an oxidizing agent, alkynes are first converted to carboxylate salts via an unstable α-diketone intermediate. Further, a mild acid treatment protonates the carboxylate anions...
6.8K
Oxidations of Aldehydes and Ketones to Carboxylic Acids
5.6K
Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
5.6K
Pyruvate Oxidation
168.7K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
168.7K


