孕妇和产后的食补充剂:证据,安全挑战和精确营养框架 (GAPSS)
Jibing Chen1, Mingyu Duan1, Zhiting Zhu1
1School of Mechanical Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Antioxidants (Basel, Switzerland)
|January 28, 2026
概括
像叶酸和铁这样的孕产妇食补充剂为怀孕结果提供了显著的好处. 然而,不一致的质量控制和某些补充剂的潜在危害需要严格的监督和个性化的方法.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 孕产妇营养不良是导致怀孕不良结果的重要危险因素.
- 食补充剂在怀孕期间通常使用,但它们的有效性,安全性和质量受到争议.
- 现有的研究往往缺乏针对怀孕的质量控制和个性化方法.
研究的目的:
- 批判性地审查关键孕产妇补充剂 (叶酸,铁,维生素D,,,欧米茄-3 PUFA,胆,多种微量营养素) 的证据.
- 评估这些补充剂在孕妇和产后妇女的机制,临床证据和质量保证.
- 提出个性化母婴营养的框架,并强调质量控制.
主要方法:
- 系统的文献审查和临床证据的批判性评估.
- 对关键微量营养素和补充剂的作用机制的分析.
- 商用产前补充剂质量控制问题的评估.
- 关于基因型-分析-生理学-安全-可持续性 (GAPSS) 框架的建议.
主要成果:
- 叶酸和铁补充剂显著减少神经管缺陷和母体贫血.
- 高剂量的抗氧化剂补充剂 (维生素C+E) 显示没有益处和潜在危害.
- 很大一部分产前补充剂含有未申报的污染物或错误的剂量.
- 先进的分析技术对于确保补充品质至关重要.
结论:
- 虽然叶酸和铁等特定补充剂是有益的,但其他需要谨慎.
- 迫切需要改善产妇补充剂的质量控制和先进的分析方法.
- 拟议的GAPSS框架为实现个性化和更安全的孕产妇营养策略提供了一条道路.
- 以生物标志物为指导的补充和严格的质量控制对于优化母亲和婴儿健康结果至关重要.
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