安托和代谢疾病:精准营养的新前沿
Giuseppe T Patanè1,2, Ruben J Moreira2,3, Maria de Almeida-Santos2
1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
Antioxidants (Basel, Switzerland)
|January 28, 2026
概括
安西氨酸在代谢综合征 (MetS) 中表现有前途,但由于生物可用性,其有效性各不相同. 使用多omics数据的精准营养可以个性化安托干预,以获得更好的健康结果.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 遗传学 是一个遗传学.
背景情况:
- 代谢综合征 (MetS) 是一个由炎症和氧化应激 (OS) 驱动的全球健康问题.
- 目前的治疗方法往往由于MetS的复杂性,多因素性质而不足.
- 安托素 (ACN) 具有对MetS有益的抗氧化和抗炎性质.
研究的目的:
- 探索安东素 (ACN) 在治疗代谢综合征 (MetS) 的潜力.
- 为了解决与生物可用性相关的ACN疗效的个体间变异性.
- 提出精准营养作为一种优化基于ACN的干预策略.
主要方法:
- 审查有关安托素,代谢综合征和精密营养的现有文献.
- 分析遗传多态化和肠道微生物在ACN代谢中的作用.
- 整合多omics数据 (基因组学,元基因组学,代谢组学) 用于个性化的ACN策略.
主要成果:
- 在ACN中表现出性作用,包括Nrf2/ARE通路调节和NF-κB抑制.
- 低系统生物可用性和个体间的可变性限制了ACN的治疗疗效.
- 肠道微生物组和宿主遗传学显著影响ACN吸收,新陈代谢和分泌 (ADME).
结论:
- 个性化营养方法对于克服ACN生物可用性挑战至关重要.
- 整合多omics数据可以预测个人对ACN的反应.
- 精密营养提供了一种途径,以最大限度地提高ACN的代谢和抗氧化益处,以预防和管理MetS.
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