神经退行性疾病中的氧化应激和溶酶体功能障碍:潜在的机制和纳米治疗向策略
Yuhe Hu1, Zhaofei Yang1, Xu Wang1
1Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian 116021, China.
Antioxidants (Basel, Switzerland)
|January 28, 2026
概括
氧化应激和 lysosomal 功能障碍创造了一个有害的循环驱动神经退行性疾病 (NDD). 纳米疗法提供了一种有希望的策略,以准这种恶性循环,并开发有效的NDD治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 纳米技术 纳米技术
背景情况:
- 神经退行性疾病 (NDD) 的特点是神经元的逐渐丧失,对全球健康造成重大负担.
- 氧化应激和溶酶体功能障碍是NDD的关键病原性因素,形成一个有害的循环.
- 这一循环涉及有机细胞交叉,加速神经元退化,恶化疾病的结果.
研究的目的:
- 系统地审查NDD中氧化应激和溶酶体功能障碍之间的相互作用.
- 突出 lysosome-mitochondria轴功能障碍在 NDD 发病过程中的中心作用.
- 批判性地评估基于纳米技术的针对性治疗NDDs.
主要方法:
- 文献综述侧重于将氧化应激与溶酶体功能障碍联系起来的分子机制.
- 在神经退行症的背景下分析溶酶体-线粒体轴.
- 对NDDs当前纳米治疗策略的评估.
主要成果:
- 过度反应性氧物种 (ROS) 损害了 lysosomal 酸化和膜完整性.
- 溶解体功能障碍阻碍了受损的线粒体和有毒聚合物的清除,加剧了ROS积累.
- lysosome-mitochondria轴是这种病理恶性循环的关键媒介.
结论:
- 传统的NDD疗法面临着诸如血脑屏障透和有针对性的干预等挑战.
- 纳米疗法由于其可调节性质和功能设计,提供了一种变革性的方法.
- 本综述为开发新型纳米疗法提供了一个框架,以针对NDD的核心病理循环.
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