相关实验视频
Updated: Jan 29, 2026

06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
35.0K
富勒眼滴通过抑制氧化应激和细胞衰老来缓解UVB诱导的白内障进展
Lele Zhang1, Shuying Chen2, Zihao Yu1
1Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Antioxidants (Basel, Switzerland)
|January 28, 2026
概括
在临床前模型中,富勒眼液通过减少氧化应激和细胞损伤,在预防白内障方面表现有前途. 这种纳米药物可能提供一种非侵入性的方法来延迟白内障的进展.
科学领域:
- 眼科医生 眼科 眼科
- 纳米医学是一种纳米医学.
- 细胞生物学 细胞生物学
背景情况:
- 白内障是全球失明的主要原因.
- 目前的治疗方法仅限于手术,没有经过验证的药理选择.
- 氧化应激和细胞衰老有助于白内障的发展.
研究的目的:
- 调查Fullerenol,一种新型纳米药物,作为延迟白内障发病和进展的潜在治疗方法.
- 在临床前白内障模型中评估局部富勒的疗效.
主要方法:
- 利用UVB诱导的老鼠白内障模型.
- 评估了Fullerenol对镜片透明度和组织学的影响.
- 研究了富勒醇对氧化应激,线粒体功能,DNA损伤和人类镜片上皮细胞衰老的影响.
- 进行了RNA测序和途径丰富分析.
主要成果:
- 局部富勒在小鼠模型中保持了透镜透明度和组织完整性.
- 富勒减少了氧化应激,改善了线粒体功能,减轻了DNA损伤,并抑制了人类镜片细胞的衰老.
- 包括MAPK,TGF-β和p53-CDKN1A轴在内的信号通路被Fullerenol.
结论:
- 富勒显示出作为一种纳米药物的潜力,可以减轻与白内障相关的光氧化损伤和细胞功能障碍.
- 这些发现支持Fullerenol作为治疗白内障的有希望的非侵入性策略.
相关概念视频
Feedback Inhibition
57.1K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.1K
Oxidation Numbers
42.5K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.5K
Replicative Cell Senescence
4.4K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.4K
Responses to Salt Stress
14.5K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.5K
Pyruvate Oxidation
168.7K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
168.7K
Oxidation-Reduction Reactions
75.5K
Oxidation–Reduction Reactions
75.5K

