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Updated: Jan 29, 2026

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氧化应激,微量营养素缺乏和腹手术后的凝血障碍:一个系统性审查
Katarzyna Giedzicz1, Przemysław Zubrzycki1, Aleksander Łukaszewicz1
12nd Clinical Department of General, Gastroenterological and Oncological Surgery, Medical University of Bialystok, 15-089 Bialystok, Poland.
Antioxidants (Basel, Switzerland)
|January 28, 2026
概括
代谢性减肥手术 (MBS) 可以破坏血液凝固,增加血栓或出血的风险. 监测氧化应激和营养水平对于管理MBS后的血静至关重要.
科学领域:
- 内分泌学和新陈代谢学
- 血液学 血液学 血液学
- 营养科学 营养科学
背景情况:
- 代谢性减肥手术 (MBS) 显著影响代谢,炎症和营养状态.
- 这些变化可以通过氧化还原依赖途径影响静血平衡.
- 了解这些变化是管理术后并发症的关键.
研究的目的:
- 系统地审查MBS后的凝血障碍.
- 强调氧化应激和微量营养素缺乏的作用.
- 评估它们对静血平衡的影响.
主要方法:
- 在PubMed,Scopus和Web of Science (2000-2025) 的系统文献搜索.
- 纳入标准适用于1707个已识别的记录,其中21项研究符合要求.
- 分析的重点是凝血参数,氧化应激标志物和营养状况.
主要成果:
- 虽然MBS通常可以减少炎症和氧化负担,但有些患者会持续出现氧化还原失衡.
- 观察到D-二聚体或威尔布兰德因子 (vWF) 的升高以及纤维解质正常化延迟.
- 常见的微量营养素缺乏 (维生素K,B12,叶酸,Se,Zn,Cu) 有助于血栓和出血风险.
结论:
- 在MBS后,氧化应激,营养状况和静血是相互关联的.
- 个性化血栓预防和常规微量营养素监测是必不可少的.
- 长期生物化学监测和标准化生物标志物面板是改进战略所必需的.
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