非常低密度脂蛋白数量但不是组成在正常甘油三症患者中发生变化,他们的脂蛋白 (a) 水平升高
Ewa Wieczorek-Breitzke1,2, Martyna Feliksiak2, Agnieszka Kuchta1
1Department of Clinical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-211 Gdansk, Poland.
International journal of molecular sciences
|January 28, 2026
概括
具有高脂蛋白 (a) (Lp(a)) 的个体具有更多的,但组成不变的,富含甘油三的非常低密度脂蛋白 (VLDL) 颗粒. 这表明,增加的VLDL颗粒数量有助于正常甘油三血症患者的心血管疾病风险.
科学领域:
- 心血管科学 心血管科学
- 脂质代谢 脂质代谢是什么
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 心血管疾病 (CVD) 的风险与 lipoprotein 代谢的改变有关,特别是富含甘油三的 lipoproteins (TRLs) 和 lipoprotein (a) (Lp(a)).
- 在没有心血管事件和正常甘油三水平的个体中,对Lp (a) 与非常低密度脂蛋白 (VLDL) 的相互作用存在有限的数据.
研究的目的:
- 为了研究VLDL的组成和度在正常甘油三血症的个体与不同的Lp (a) 水平.
- 在没有高甘油三血症或之前的CV事件的情况下,探索Lp(a) 和VLDL颗粒特征之间的关系.
主要方法:
- 七十名正常甘油三血症成年人 (甘油三血糖<150 mg/dL,没有CV事件) 按Lp (a) 度 (<30 mg/dL与≥30 mg/dL) 分组.
- 通过超离心法分离出VLDL.
- 测量了血清和VLDL中的Lp (a),脂质 (三甘油,胆固醇) 和阿波利波蛋白 (apo B,apo C-II,apo C-III,apo E) 的度.
主要成果:
- 血清脂和阿波利波蛋白水平在各组之间没有差异.
- 患有Lp (a) ≥30 mg/dL的个体表现出显著更高的VLDL甘油三化物度 (+71%),胆固醇 (+54%),apo B (+28%),apo C-II (+36%),和apo C-III (+33%).
- 对脂质和阿波利波蛋白与阿波B的比率的分析表明VLDL粒子组成没有变化,这表明粒子数量增加.
结论:
- 患有Lp (a) ≥30 mg/dL的正常甘油三血症个体具有更丰富的VLDL颗粒,没有改变VLDL组成.
- 这种增加的VLDL颗粒数可能会导致剩余的心血管风险.
- 对VLDL-Lp (a) 相互作用的进一步研究是有必要的,以了解它们在心血管疾病发病过程中的作用.
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