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放射性囊炎的尿路生物标志物:当前见解和未来方向
Rani Mahyoob1, Bernadette M M Zwaans1,2
1Department of Urology, Corewell Health William Beaumont University Hospital, Royal Oak, MI 48073, USA.
International journal of molecular sciences
|January 28, 2026
概括
本综述探讨了用于诊断放射性囊炎 (RC) 的尿路生物标志物,这是盆腔放射治疗的一个具有挑战性的并发症. 了解这些分子签名可以导致更早的检测和更好的患者结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 放射性囊炎 (RC) 是盆腔放射治疗的渐进性并发症.
- 由于非特异性症状和缺乏经过验证的分子工具,目前的诊断具有挑战性.
- 尿液是了解RC病变的宝贵生物流体.
研究的目的:
- 审查急性,潜伏性和慢性阶段的尿路生物标志物RC.
- 整合机理性见解到RC病原和尿分析物释放.
- 突出基于尿的诊断在RC的机会.
主要方法:
- 关于RC的尿路生物标志物的当前文献的全面审查.
- 合成分子通路和相应的尿路特征.
- 整合机械洞察力,包括DNA损伤,氧化应激和纤维化.
主要成果:
- 在RC阶段识别出各种尿路生物标志物 (细胞因子,氧化应激产物,EV,miRNA等). ) 的情况.
- 将分子机制 (ROS,缺氧,TGF-β) 与尿分析物概况联系起来.
- 突出了尿基测量在早期检测,风险分层和监测方面的潜力.
结论:
- 尿路生物标志物为早期和准确诊断RC提供了一个有希望的途径.
- 了解分子机制是开发有效的尿基诊断工具的关键.
- 使用尿路形状的精确诊断可以改善RC患者的长期结果.
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