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Updated: Jan 29, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
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坎-10-硫胺氨基酸:合成,抗病毒评估和分子对接洞察力

Krasimira Dikova1,2, Neli Vilhelmova-Ilieva3, Emilio Mateev4

  • 1Laboratory Organic Synthesis and Stereochemistry, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

International journal of molecular sciences
|January 28, 2026
PubMed
概括

新的硫胺衍生物对简单疹病毒1型,人类冠状病毒OC43和猫病毒具有广泛的抗病毒活性. 托衍生物7a显示出病毒吸附和杀毒效应的强烈抑制,这表明有可能开发新的抗病毒药物.

关键词:
在FCV中,FCV是FCV.在HSV-1病毒中,抗病毒活动的抗病毒活性.基于坎佛的硫胺基.有可能的合成.人类新冠肺炎病毒分子对接的分子对接.病毒吸附病毒吸附.病毒杀伤性活动.

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Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
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During hydrolysis, the ester is first activated towards nucleophilic attack through the protonation of the carboxyl oxygen atom by the acid catalyst. The protonation makes the ester carbonyl carbon more electrophilic. In the next step, water acts as a nucleophile and adds to the...
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Esters can be hydrolyzed to carboxylic acids under acidic or basic conditions. Base-promoted hydrolysis of esters is a nucleophilic acyl substitution reaction in which esters react with an aqueous base, followed by an acid to give carboxylic acids. This reaction is also known as saponification because it forms the basis for making soaps from fats.
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