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转录基因分析确定了与阿克罗莱因暴露相关的途径,并在口腔状细胞癌中构建了一个预后模型
Yiting Feng1,2, Lijuan Lou1, Liangliang Ren1
1State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
International journal of molecular sciences
|January 28, 2026
概括
暴露于阿克罗莱因与口腔癌 (OSCC) 有关. 这项研究确定了四个关键基因 (PLK1,AURKA,CTLA4,PPARG) 来预测OSCC的预后和存活率,突出了环境毒素.
科学领域:
- 环境毒理学和癌症研究.
- 分子瘤学和癌症基因组学.
- 发现用于癌症预后的生物标志物.
背景情况:
- 城市空气和烟雾中的环境毒素阿克罗莱因与各种癌症有关.
- 在口腔组织中长期暴露于阿克罗莱因会导致氧化应激,炎症和突变,促进口腔状细胞癌 (OSCC).
- 在OSCC中,阿克罗莱因暴露的预后价值仍然不清楚.
研究的目的:
- 识别与OSCC相关的与蛋白相关的基因.
- 根据这些基因开发和验证OSCC的预后模型.
- 为了研究与阿克罗莱因相关的基因和瘤免疫微环境之间的关系.
主要方法:
- 转录组数据分析以确定OSCC组织中的差异表达基因 (DEG).
- DEGs与阿克罗莱因相关基因组的交叉.
- 基因组变异分析 (GSVA),蛋白质-蛋白质相互作用 (PPI) 网络构建,支持矢量机-递归特征消除 (SVM-RFE) 和LASSO-Cox回归用于模型开发和验证.
主要成果:
- 确定了四个关键的与阿克罗莱因相关的基因 (PLK1,AURKA,CTLA4,PPARG) 用于预后模型的构建.
- 开发的预后模型显示出强大的预测性能 (AUC为0.72-0.75在1-5年) 并在外部队列中得到验证.
- 高风险得分与"寒冷"的免疫微环境相关,表明与阿克罗莱因相关的基因调节瘤免疫力.
结论:
- 阿克罗林在OSCC进展中起着重要作用.
- 鉴定出来的基因特征是OSCC的一个有前途的预后生物标志物.
- 减少阿克罗莱因暴露对预防癌症和公共卫生至关重要,强调环境毒素和疾病之间的联系.
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