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聚糖在肠肝轴上通过调节Muribaculaceae衍生SCFA来缓解MASLD

Yang Yang¹, Hong Wang², Yiqing Gu¹

¹School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Road, Beijing 100029, China.

International journal of molecular sciences

|January 28, 2026

概括

布普鲁里根多糖 (Bupleuri radix polysaccharides,BRP) 通过增强有益的肠道细菌和短链脂肪酸来缓解与代谢功能障碍相关的脂肪性肝病 (MASLD). 这种方法改善了肝脏健康和肠道屏障功能,为MASLD提供了一种新的治疗策略.

科学领域:

传统中国医药传统中国医药
药理学药理学是指药理学的学科.
胃肠病学胃肠病学

背景情况:

布普勒瑞根被认为具有保护肝脏的特性.
多糖是Bupleuri radix.中的关键生物活性化合物.
布普勒里基多糖 (Bupleuri radix polysaccharides,BRP) 对代谢功能障碍相关的脂肪性肝病 (MASLD) 的影响尚不清楚.

研究的目的:

为了识别具有抗MASLD活性的BRP分数.
阐明BRP对MASLD的影响的机制.
探索BRP作为MASLD治疗剂的潜力.

主要方法:

BRP的制备和物理化学表征.
在MASLD模型中评估BRP对肝损伤和肠壁功能的影响.
整合转录学和代谢学,以获得机械学见解.
16S rRNA测序以分析肠道微生物群的组成.
评估与特定细菌物种的协同效应.

主要成果:

在MASLD.中,BRP显著减少了肝损伤,并恢复了肠道屏障的完整性.
BRP调节了肠道微生物群,丰富了短链脂肪酸 (SCFA) 生产细菌,如Muribaculaceae.
BRP增加了肠道酸和酸水平,这与AMPK激活和肝脏中的胆固醇代谢有关.
在改善肝脏和结肠损伤方面,Paramuribaculum intestinale与BRP表现出协同作用.

结论:

BRP通过调节肠肝轴通过Muribaculaceae的SCFA生产来改善MASLD.
BRP的机制包括恢复肠道屏障功能和调节肝脂代谢.
结合使用BRP和益生菌,为MASLD提供了一个有前途的治疗策略.

关键词:

布普勒尤里根基多糖化物.马斯尔德马斯尔德是什么意思这种植物是Muribaculaceae.这种植物叫做Paramuribaculum intestinale.在SCFAs中,SCFAs是最重要的.

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