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母胎对基元素的暴露及其对妊娠结果的氧化和表观遗传影响

Joanna Grzesik-Gąsior¹, Agnieszka Bień², Katarzyna Zalewska¹

¹State University of Applied Sciences in Krosno, Rynek 1, 38-400 Krosno, Poland.

International journal of molecular sciences

|January 28, 2026

概括

母亲的微量营养素和有毒金属水平显著影响怀孕和胎儿发育. 了解这些元素对于胎盘功能和产科结果至关重要,带血液是关键的暴露生物标志物.

科学领域:

生殖生物学生殖生物学
环境健康环境健康
毒理学毒理学毒理学

背景情况:

适当的母体微量营养素对于健康的怀孕和胎儿发育至关重要.
元素,包括必不可少的矿物质 (,,铜) 和有毒金属 (,,),影响胎盘功能和产科结果.
过度接触有毒金属可以在怀孕期间破坏荷尔蒙,表观遗传和氧化均质.

研究的目的:

审查选定的oncoelements对胎盘功能和产科结果的影响.
将分子机制,胎盘保护,临床结果和带血生物标志物整合到一个概念模型中.
总结当前关于怀孕中必不可少和有毒元素的知识.

主要方法:

综合性,概念驱动的叙事审查.
围绕一个四层次的概念模型构建:分子机制,胎盘保护,临床结果和带血.
综合现有关于碳元素及其在怀孕期间影响的研究.

主要成果:

有毒金属 (,,) 和保护元素 (,,铜) 不同地影响怀孕.
毒性的机制包括氧化应激,线粒体功能障碍,DNA损伤和基因表达的改变.
带血是产前暴露的有希望的生物标志物,尽管方法的变化.

结论:

对微量营养素评估和有毒金属查的临床建议需要进一步验证,特别是在高风险或环境负担较高的人群中.
未来的研究应该专注于剂量反应关系,值度和分子生物标志物.
为了准确解释胎儿暴露,需要对带血分析进行标准化,并建立参考值.

关键词:

这是带血,带血.延迟的效果延迟的效果重金属重金属的使用.氧化应激是一种氧化应激.胎盘胎盘胎盘胎盘怀孕怀孕怀孕怀孕怀孕在产前暴露,产前暴露.微量元素的微量元素是什么

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