复杂茶叶提取物和后生物BPL1®HT对改善与小鼠代谢综合征相关的心脏代谢变化的增强作用
Mario de la Fuente-Muñoz1, Marta Román-Carmena1, Sara Amor1
1Physiology Department, School of Medicine, Universidad Autonoma de Madrid, 28029 Madrid, Spain.
International journal of molecular sciences
|January 28, 2026
概括
绿茶/黑茶提取物 (CTE) 和热处理后生物 (BPL1® HT) 的组合协同对抗小鼠的代谢综合征 (MetS). 这种营养策略使代谢标记正常化,改善血管功能,并积极调节肠道微生物群组成.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 心血管研究研究心血管研究
背景情况:
- 代谢综合征 (MetS) 是一组疾病,包括肥胖,胰岛素耐药性,脂质失调和高血压.
- 这些情况显著提高了患2型糖尿病和心血管疾病的风险.
- 当前的治疗策略往往侧重于单个组件,需要探索互补的方法.
研究的目的:
- 评估绿色和黑色标准化ADM复合茶提取物 (CTE) 和热处理后生物 (BPL1® HT) 对MetS.的协同作用.
- 研究CTE和BPL1® HT单独或组合对代谢,炎症,氧化和血管参数的影响.
- 为了评估这些干预措施对肠道微生物群组成的影响,在MetS的小鼠模型中进行了评估.
主要方法:
- 在20周的时间里,C57BL/6J小鼠接受了高脂肪/高糖 (HFHS) 饮食.
- 小鼠接受了口服CTE,BPL1® HT或它们的组合.
- 综合分析包括代谢分析,器官评估,炎症和氧化应激标志物评估,血管功能测试和便微生物群测序.
主要成果:
- 无论是CTE还是BPL1® HT,各自都改善了新陈代谢参数,并减少了炎症.
- 组合疗法显示出协同效应,完全正常化体重,脂肪细胞大小,脂质配置文件和胰岛素敏感性.
- 同时治疗恢复了关键信号通路 (PI3K/Akt),减少了肝硬化,改善了血管功能,并有益地调节了肠道微生物群,增加了细菌丰富性和改变了特定的细菌种群.
结论:
- 结合使用CTE和BPL1® HT,可以提供一种有效的营养策略来对抗MetS.
- 协同效应通过互补机制进行调节,包括增强胰岛素信号传递,减少炎症和氧化应激,改善血管健康和肠道微生物群调节.
- 这种组合为管理与代谢综合征相关的心脏代谢并发症提供了有希望的途径.
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