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Updated: Jan 29, 2026

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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构成性活跃的Stat5b在树突细胞中的表达增强了Treg介导的自反应性CD8+ T细胞在自身免疫糖尿病中的消除

Puregmaa Khongorzul1, Farhan Ullah Khan1, Daphnée Levasseur1

  • 1Department of Pediatrics, Immunology Division, Faculty of Medicine and Health Sciences, Centre de Recherche du CHUS, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC J1H 5N4, Canada.

International journal of molecular sciences
|January 28, 2026
PubMed
概括

在树突细胞 (DC) 中具有构成活性的Stat5b在1型糖尿病 (T1D) 模型中增强了调节性T细胞 (Tregs) 功能. 这增强了Treg细胞毒性,减少了致病性CD8+T细胞,并防止了糖尿病.

关键词:
统计 统计 统计免疫力是一种免疫力.监管T细胞的监管性T细胞这是一个宽容的宽容度.第1类糖尿病 1型糖尿病

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