心血管疾病和法医应用中的微RNA:诊断和尸检后影响的系统审查
Matteo Antonio Sacco1, Saverio Gualtieri1, Maria Cristina Verrina1
1Institute of Legal Medicine, Department of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.
International journal of molecular sciences
|January 28, 2026
概括
微RNAs (miRNAs) 作为诊断心血管疾病和突然死亡的生物标志物,即使在降解的样本中也是有前途的. 它们的稳定性使得它们成为法医病理学的宝贵工具,尽管常规使用需要标准化.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 法医科学 法医科学 法医科学
背景情况:
- 微RNA (miRNA) 是小型非编码RNA,在转录后调节基因表达.
- 它们的稳定性和组织特异性使它们成为临床和法医应用的潜在生物标志物.
- 微RNA因其在心血管疾病中的作用越来越被认可,提供了诊断和预后潜力.
研究的目的:
- 系统地审查miRNAs在心血管病理学中的作用.
- 评估它们在心肌梗塞,心脏突然死亡和心肌病的诊断潜力.
- 评估它们在死后法医调查中的适用性.
主要方法:
- 按照PRISMA指南进行系统的文献审查.
- 在PubMed,Scopus和Web of Science数据库中搜索到2024年12月.
- 专注于研究研究miRNA在心血管疾病和法医环境中的实用性.
主要成果:
- 几种miRNAs (例如miR-1,miR-133a,miR-208b,miR-499a,miR-486-5p) 是缺血损伤和突然死亡的强有力的标记物.
- 即使在降解或甲胺固定的尸检样本中,miRNA仍然可以检测和可靠.
- 在极端的死后条件下,miRNA的高稳定性支持它们的法医潜力.
结论:
- miRNAs是诊断心血管事件和突然死亡的有希望的生物标志物.
- 它们在具有挑战性的法医样本中的稳定性凸显了它们在法医病理学中的实用性.
- 为了常规的临床和法医应用,需要在大型队列中进一步标准化和验证.
相关概念视频
MicroRNAs
24.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
MicroRNAs
4.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.0K
Psychoneuroimmunology: Cardiovascular Disease
475
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
475
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
570
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
570


