在长期COVID患者中可能涉及下丘脑功能障碍,这些患者的特征是对释放性荷尔蒙 (Gonadotropin) 的反应延迟
Yuki Otsuka1, Yoshiaki Soejima1, Yasuhiro Nakano1
1Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
International journal of molecular sciences
|January 28, 2026
概括
长期COVID患者可能会出现下丘脑功能障碍,在垂体刺激测试中通过延迟的激素反应表明. 这表明功能问题而不是永久性垂体损伤,需要仔细的内分泌评估.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID (LC) 与潜在的内分泌功能障碍有关,但机制尚不清楚.
- 在LC中下丘脑-垂体轴的功能需要进一步的研究.
研究的目的:
- 为了研究耐火性长期COVID患者的下丘脑-垂体反应.
- 在LC中区分原发性垂体损伤和功能性下丘脑功能障碍.
主要方法:
- 对16名长期COVID患者进行前垂体刺激测试 (CRH,TRH,GnRH) 的回顾性研究.
- 纳入标准:耐火性LC与低随机ACTH/皮质醇水平.
- 分析了荷尔蒙反应 (ACTH,TSH,PRL,FSH,LH,GH) 和IGF-I水平.
主要成果:
- 保持高峰荷尔蒙反应,但观察到ACTH,LH和FSH的延迟高峰 (超过60分钟).
- 显著延迟的TSH,PRL,LH和FSH的升高持续了120分钟,这表明下丘脑的参与.
- 观察到血清IGF-I水平较低;GH对GHRP-2的GH反应得到保留.
结论:
- 在长期COVID患者中观察到的反应模式与功能性二级下丘脑功能障碍一致.
- 研究结果表明,在开始激素替代疗法之前,内分泌评估至关重要.
- 该研究强调了在长期COVID管理中需要客观的内分泌评估.
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