潘达努斯 (Pandanus amaryllifolius) 和Tectona grandis的提取物改善了大鼠中链毒素诱导妊娠糖尿病的胎儿结果
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Sasitorn Kerdsuknirund1, Pakanit Kupittayanant2, Pattama Tongdee3,4
1School of Preclinical Sciences, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
International journal of molecular sciences
|January 28, 2026
概括
这项研究表明,潘丹-泰克草药配方在妊娠糖尿病 (GDM) 的老鼠中改善了孕产妇和胎儿的结果. 基于植物的方法支持胎儿生长,同时保持母亲的血糖稳定性.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 生殖生物学 生殖生物学
- 自然产品化学 自然产品化学
背景情况:
- 孕期糖尿病 (GDM) 对母亲和胎儿的健康构成重大风险.
- 现有的GDM治疗方法可能存在局限性,需要探索替代治疗策略.
- 多草药配方由于潜在的协同效应,为管理GDM提供了一个有希望的途径.
研究的目的:
- 在GDM的动物模型中评估多草药配方 (Pandan-Teak) 的疗效.
- 为了比较Pandan-Teak配方与甲胺对母亲和胎儿参数的影响.
- 调查配方对母亲体重,胰腺功能和胎儿发育的影响.
主要方法:
- 在怀孕的老鼠中使用了链毒素 (STZ) 诱导的GDM作为实验模型.
- 动物从怀孕的第7天到第21天接受了Pandan-Teak配方或甲福明的不同剂量治疗.
- 评估了母亲的体重,血糖水平,胰岛素,胰腺质量指数和胎儿/胎盘参数.
主要成果:
- 中高剂量Pandan-Teak配方显著增加了母亲的体重和胰腺质量指数.
- 胎儿体重和冠长度与配方的剂量依赖性增加.
- 胎盘指数和胎儿葡萄糖水平以剂量依赖的方式显著下降,而不会影响植入损失.
结论:
- 潘丹-蒂克配方在支持胎儿生长和胎盘-胎儿葡萄糖调节方面显示出潜力.
- 该配方可以为GDM提供基于植物的辅助疗法,重点是保护胎儿,同时保持母亲的血糖稳定性.
- 需要进一步的研究来探索这种多草药方法对妊娠糖尿病的机制和临床适用性.
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