青光 CD8+CCR7+CD45RA- T 细胞作为一种与 CAR T 细胞动力学和临床结果相关的新生物标志物
Iván García de la Torre1, Carlota García-Hoz1, Fernando Martin-Moro2
1Department of Immunology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
International journal of molecular sciences
|January 28, 2026
概括
高CD8+的中央记忆T细胞 (TCM) 在异位样本中预测了接受CAR T细胞治疗的复发或耐药的大B细胞淋巴瘤患者的更好的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞疗法细胞疗法
背景情况:
- 化学抗原受体 (CAR) T细胞疗法,包括 axicabtagene ciloleucel (axi-cel),已经改变了复发或不耐药的扩散大B细胞淋巴瘤 (DLBCL) 的治疗方法.
- 然而,许多患者无法获得持久的反应,这凸显了需要预测生物标志物来指导治疗决策的必要性.
- 识别预治疗因素,预测CAR T细胞治疗的成功对于优化患者的治疗结果至关重要.
研究的目的:
- 在与CAR T细胞扩张相关的异位样本中识别治疗前的T淋巴细胞生物标志物,以及在复发或耐药的大B细胞淋巴瘤 (LBCL) 患者的临床结果.
- 评估特定T细胞亚种群对CAR T细胞动力学和轴细胞治疗后患者存活率的预测值.
主要方法:
- 用多参数流细胞计量检测免疫型T细胞亚群在23个月/月的LBCL患者的非样本中,这些患者接受了轴细胞治疗.
- 输液后对循环中的CAR T细胞进行了监测.
- 进行了统计分析,以将T细胞频率与CAR T细胞扩张和无进展生存率相关联.
主要成果:
- 在CAR T细胞扩张强度 (≥45.2细胞/毫升) 的患者中,CD4+和CD8+中央记忆T细胞 (TCM;CCR7+CD45RA-) 的频率较高,CD8+CD38+T细胞的比例较低.
- 在表样本中CD8+TCM细胞的治疗前切断值>4.3%预测了强大的CART细胞扩张 (AUC:0.80;p=0.023).
- 更高的CD8+TCM细胞频率与更高的无进展生存率相关 (p=0.04).
结论:
- 在治疗前的异位样本中CD8+中央记忆T细胞 (TCM) 的高频率是预测强大的CAR T细胞扩张的有希望的生物标志物.
- 这种生物标志物也与治疗轴细胞的复发性或耐药性LBCL患者的改善临床结果,特别是无进展的存活率有关.
- 这些发现表明,CD8+ TCM细胞水平可以帮助患者选择和预测CAR T细胞治疗.
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