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多发性硬化症的慢性疼痛:机制,临床特征和治疗策略
Panagiotis Gklinos1, Georgia Christodoulou1, Dorothea Pournara1
11st Department of Neurology, Eginition University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
International journal of molecular sciences
|January 28, 2026
概括
慢性疼痛影响了许多患有多发性硬化症 (MS) 的患者,影响了他们的生活质量. 了解MS的疼痛机制是开发个性化治疗以获得更好的结果的关键.
科学领域:
- 神经学 神经学
- 疼痛医学 医学 疼痛医学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性疼痛在患有多发性硬化症 (pwMS) 的人群中非常普遍,从23%到90%不等.
- 这种症状显著损害了 pwMS 的生活质量和功能结果.
- 目前对MS慢性疼痛的理解和治疗往往是不充分的.
研究的目的:
- 提供多发性硬化症慢性疼痛病理生理机制的最新审查.
- 提出一种基于MS的慢性疼痛的机制分类.
- 根据已识别的疼痛机制,探索量身定制的治疗方法.
主要方法:
- 在MS中慢性疼痛的病理生理机制的文献综述.
- 分析神经病变性,感觉性和可感觉性疼痛机制之间的相互作用.
- 探索药理和非药理治疗策略.
主要成果:
- 多发性硬化症的慢性疼痛涉及神经病变,痛感和痛感细胞机制之间的复杂相互作用.
- 建议基于机制的分类,以更好地分类疼痛表型.
- 不同的治疗干预措施,无论是药理还是非药理,都可以根据特定的机制量身定制.
结论:
- 更深入地了解MS中独特的慢性疼痛机制和表型至关重要.
- 基于基于机制的分类的个性化治疗策略可以改善患者的治疗结果.
- 慢性疼痛的有效管理可以提高MS患者的生活质量.
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