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在人类血清中通过LC-MS/MS同时对ManNAc和Neu5Ac进行量化.

Gerardo N Guerrero-Flores1,2, Fabio J Pacheco1, Veronica L Martinez Marignac3

  • 1Centro Interdisciplinario de Investigaciones en Ciencias de la Salud y del Comportamiento (CIICSAC), Facultad de Ciencias de la Salud, Universidad Adventista del Plata, 25 de Mayo 99, Libertador San Martín 3103, Argentina.

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血清中N-乙-D-曼诺胺 (ManNAc) 和N-乙神经胺酸 (Neu5Ac) 的水平因种族,性别,年龄和BMI而异. 这项研究开发了一种精确的LC-MS/MS方法来量化这些糖化成分.

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这就是为什么BMI是BMI.这是LC-MS/MS.这就是ManNAcc.新型5AcAc是什么意思年龄的年龄年龄的年龄.饮食 饮食 饮食 饮食民族身份 民族身份在性爱中,性爱是性爱.

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科学领域:

  • 生物化学 生物化学
  • 分析化学 分析化学
  • 人体生理学 人体生理学

背景情况:

  • N-乙-D-曼诺胺 (ManNAc) 和N-乙神经胺酸 (Neu5Ac) 对于糖化和生理功能至关重要.
  • 年龄,BMI,种族和性别等人口统计因素对血清ManNAc和Neu5Ac水平的影响在很大程度上仍未被描述.

研究的目的:

  • 开发和验证一种敏感的液体染色学-并联质谱法 (LC-MS/MS) 方法,用于同时量化人类血清中的ManNAc和Neu5Ac.
  • 在人类队列中研究血清ManNAc和Neu5Ac水平与人口因素 (年龄,BMI,种族,性别) 之间的关联.

主要方法:

  • 开发和验证用于血清ManNAc和Neu5Ac.Ac的同时LC-MS/MS测定.
  • 分析了来自第2次基督复临教会健康研究 (AHS-2) 队列的155个血清样本.
  • 统计分析以确定分析剂水平和人口统计变量之间的相关性.

主要成果:

  • 血清neu5ac水平在女性中显著更高 (p=0.029对结合,p=0.026对总).
  • 与白人参与者相比,黑人参与者的结合和总ManNAc水平显著更高 (p < 0.001).
  • 较高的BMI与增加的自由ManNAc相关 (p=0.041),而年龄较大与较高的自由和总ManNAc相关 (分别p ≤0.001和p=0.045).

结论:

  • 经过验证的LC-MS/MS方法提供了血清ManNAc和Neu5Ac的敏感和特定量化.
  • 血清中ManNAc和Neu5Ac的度受种族,性别,年龄和BMI的影响.
  • 这种方法将使进一步研究这些糖化成分的生理作用和临床相关性成为可能.