在受控卵巢过度刺激期间显示增加STAT5酸化的循环天真调节性T细胞子集与临床怀孕和孕激素水平有关
Ksenija Rakić1,2, Aleš Goropevšek2,3, Nejc Kozar1,2
1Department of Reproductive Medicine and Gynaecological Endocrinology, Clinic for Gynaecology and Perinatology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia.
International journal of molecular sciences
|January 28, 2026
概括
调控性T细胞 (Treg) 亚群对于成功的胚胎植入至关重要. 原始的CXCR5-Treg与怀孕和孕激素水平相关,这表明Treg对辅助生殖的分析.
科学领域:
- 生殖免疫学 生殖免疫学
- 细胞免疫学 细胞免疫学
- 内分泌学 在内分泌学.
背景情况:
- 在胚胎植入期间,母亲的免疫耐受性依赖于调节性T细胞 (Tregs).
- 植入失败是辅助生殖的一个重大挑战.
- 特雷格频率和表型可能会影响植入成功,受荷尔蒙条件的影响.
研究的目的:
- 在受刺激的IVF/ICSI和自然FET周期中,在胚胎细胞移植日调查周围血液Treg水平和亚群.
- 检查Treg亚群,全身激素水平和抗穆勒尔激素 (AMH) 之间的关联.
主要方法:
- 对接受新鲜ET (IVF/ICSI) 和自然周期FET的妇女进行前性观察研究.
- 用于Treg亚群分析的13色流细胞计,包括CXCR5表达.
- 细胞内STAT5信号评估和测量血清雌激醇,孕激素,FSH,LH和AMH.
主要成果:
- 在怀孕和没有怀孕的女性之间观察到Treg亚群分布的显著差异.
- 较高的CXCR5-Tregs原始频率与临床怀孕有关,并与孕激素水平相关.
- 在COH周期中,原始Treg频率和依赖IL-7的STAT5信号与AMH水平相关.
结论:
- Treg亚种群,特别是原始的CXCR5-Tregs,对于植入成功至关重要.
- 在刺激周期和自然周期之间,Treg的分布有所不同,受孕激素和STAT5信号的影响.
- 外围Treg分析可以作为植入能力和个性化辅助生殖的生物标志物.
关键词:
在CD127中,CD127是指CD127中,CD127是指CD127.CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25 CD25在CXCR5中,CXCR5是CXCR5.这是FOXP3P3的.胚胎植入 胚胎的植入在体外受精体外受精.监管T细胞的监管性T细胞更多相关视频
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