草多糖通过调节肠道微生物群和通过PPARγ/NF-κB通路抑制炎症来改善子的生长
Junying Xu1,2, Fang Li1,2, Yuanxin Zhu1
1College of Animal Science and Technology, Henan Agricultural University, No. 15 Longzihu University Area, Zhengdong New District, Zhengzhou 450046, China.
International journal of molecular sciences
|January 28, 2026
概括
草多糖 (APS) 通过减少炎症和增加有益细菌,显著改善了肉的生长和肠道健康. 这种天然替代抗生素可以提高性能和肉质.
科学领域:
- 动物科学动物科学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 在肉中,断奶引起的肠道炎症导致生长延迟,影响繁殖效率.
- 的多糖 (APS) 具有抗氧化和抗炎性质,为抗生素提供了潜在的天然替代品.
- 有限的研究存在于APS在肉生产中的有效性.
研究的目的:
- 研究饮食中APS补充剂对肉生长性能,肠道炎症和肉质量的影响.
- 阐明潜在的机制,包括肠道微生物群调节和炎症途径抑制.
主要方法:
- 80只子被分为四组:对照组和三个APS补充剂水平 (400,800,1200毫克/公斤).
- 评估了生长性能 (ADG,F/G),尸体特征,肉质 (滴滴损失),肠道形态 (高,紧接口) 和炎症标志物.
- 分析了肠道微生物群的组成 (CECAL Flavonifractor) 和炎症信号通路 (PPARγ/NF-κB).
主要成果:
- 800 mg/kg APS显著增加了平均每日增益 (ADG) 和改善了料与增益比 (F/G).
- 补充APS增加了屠宰重量,内脏重量和半内脏产量,同时减少了肌肉滴水损失.
- APS增加了小肠的高度,紧密结的表达,以及产酸的细菌 (Flavonifractor),同时通过PPARγ/NF-κB抑制减少了炎症媒介.
结论:
- 饮食中的APS补充剂,特别是800 mg/kg,有效地改善了肉的生长性能和肉质.
- 通过调节肠道微生物群,增加丁酸盐水平,并通过PPARγ/NF-κB通路抑制肠道炎症来发挥其有益作用.
- APS代表了一种有前途的天然料添加剂,可以增强子生产和肠道健康.
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