在 Carotid 动脉样硬化的进展中非编码 RNA 概况: 一个系统的审查
Gemma Sardelli1, Pasquale Bufano1,2, Rosetta Ragusa1
1Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), 56124 Pisa, Italy.
International journal of molecular sciences
|January 28, 2026
概括
非编码RNAs (ncRNAs) 参与心动脉动脉样硬化进展. 本综述详细介绍了疾病各个阶段的ncRNA表达,强调了它们作为中风风险生物标志物的潜力.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 动脉样硬化是缺血性中风和神经障碍的主要原因.
- 非编码RNAs (ncRNAs) 调节基因表达并影响异构造.
- 了解ncRNA在动脉疾病中的作用对于预防中风至关重要.
研究的目的:
- 系统地审查和综合有关在动脉样硬化中的ncRNA表达的发现.
- 为了建立一个特定阶段的ncRNA表达特征,用于动脉疾病.
- 探索ncRNAs作为生物标记物和治疗点的潜力.
主要方法:
- 按照PRISMA指南,对PubMed和Scopus (2025年1月) 的系统文献搜索.
- 包括对患有动脉样硬化的人体研究和ncRNA评估的研究.
- 基于疾病进展和临床关联的研究分类.
主要成果:
- 49项研究符合纳入标准,分析了细胞内和循环中的ncRNAs.
- 微RNAs (miRNAs),圆形RNAs (circRNAs) 和长非编码RNAs (lncRNAs) 经常受到失调.
- 已识别的ncRNAs与炎症,VSMC调节和胆固醇流失有关.
结论:
- ncRNAs与动脉动脉样硬化的开始和进展有关.
- ncRNAs在脑血管疾病的脑血管并发症中起作用.
- ncRNAs显示出潜在的最小侵入性生物标志物和动脉动脉样硬化治疗点.
相关概念视频
lncRNA - Long Non-coding RNAs
9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Atherosclerosis III: Management
371
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
371
RNA Splicing
60.6K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.6K
Atherosclerosis I: Introduction
1.0K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.0K


