补充剂在老年人中部分恢复了干扰的干扰素-γ生产
Krisztina Olah1, Johanna Zenk1, Jana Jakobs1
1Institute of Immunology, Faculty of Medicine, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.
International journal of molecular sciences
|January 28, 2026
概括
老年人往往有较低的水平和免疫功能下降. 补充剂改善了老年人的免疫反应,特别是那些使用质子抑制剂的人.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 衰老与免疫功能下降和状况改变有关.
- 在免疫细胞功能和细胞因子生产中起着至关重要的作用.
- 载体ZIP8参与干扰素- (IFN-γ) 生产,但其通过人类的状态的调节尚不清楚.
研究的目的:
- 为了研究老年住院患者与年轻健康对照人群之间的状况,免疫反应 (IFN-γ产生) 和ZIP8表达之间的关系.
- 评估补充剂对这些参数在缺乏的老年人,特别是那些使用质子抑制剂 (PPI) 的老年人的影响.
主要方法:
- 评估血清,饮食摄入量,PPI使用,由植物血凝素 (PHA) 刺激的IFN-γ产生和ZIP8蛋白表达.
- 将老年住院患者与年轻的健康对照人群进行比较.
- 给缺乏的老年参与者服用酸补充剂,并评估了状态,IFN-γ和ZIP8表达的变化.
主要成果:
- 与年轻成年人相比,老年参与者表现出较低的状态和IFN-γ水平.
- 在老年人中,PPI使用与缺乏相关.
- 补充剂增加了缺陷老年人的血清和IFN-γ水平,在服用PPI的人群中观察到ZIP8表达的显著增加.
结论:
- 在老年人中,缺乏和免疫反应受损是普遍存在的.
- 补充剂可以提高老年人的免疫功能,特别是那些有缺乏症和PPI的人.
- 需要进一步的研究,以澄清链接状态,ZIP8表达和IFN-γ生产在衰老中的具体机制.
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