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柏柏林通过调节肠道屏障和炎症反应来缓解Shigella诱导的痢疾

Jinwen Ding¹, Yu Zhang¹, Xinyu Fan¹

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

International journal of molecular sciences

|January 28, 2026

概括

柏柏林 (BBR) 增强了肠道屏障功能,并调节了免疫反应,以防止Shigella flexneri引起的痢疾. 这种天然化合物增强了肠道的完整性,并平衡了治疗潜力的炎症.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

柏柏林 (BBR) 是一种异类类化合物,传统上用于治疗痢疾.
目前尚不清楚BBR治疗效果的确切机制.

研究的目的:

在小鼠模型中研究BBR对Shigella flexneri诱导的痢疾的肠道保护机制.
阐明BBR如何影响肠道屏障功能和感染期间的免疫反应.

主要方法:

鼠被感染了Shigella flexneri,并用BBR治疗.
分析了肠道屏障蛋白质 (ZO-1,奥克卢丁,E-cadherin).
评估了巨分极 (M1),T细胞子集 (Th1,Th17,Treg) 和细胞因子 (IFN-γ,IL-17A,IL-10,TGF-β1) 的情况.
测量了分泌IgA (sIgA) 的水平.

主要成果:

BBR显著提高了肠道屏障蛋白的调节,改善了粘膜的完整性,并抑制了S. flexneri的入侵.
BBR减弱了M1巨细胞两极分化,并恢复了Th1/Th17/Treg平衡.
BBR降低了促炎性细胞因子 (IFN-γ,IL-17A),同时增加了抗炎性细胞因子 (IL-10,TGF-β1).
BBR增加了分泌IgA (sIgA) 水平,进一步促进了肠道的保护.

结论:

BBR显示出对Shigella flexneri引起的痢疾有显著的保护作用.
这些效应通过增强肠道屏障功能和调节炎症和免疫反应来调节.
研究结果支持Berberine在临床上用于治疗细菌性痢疾.

关键词:

柏柏林蛋白是一种柏柏林蛋白.滋格拉菌感染的感染腹症腹症腹症炎症反应可能是炎症反应.肠道屏障肠道屏障肠道屏障

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