氧化应激及其在血管损伤和动脉样硬化中的作用
Adela Pozo Giráldez1,2, Adrián Bravo Gómez3,4, Pilar Calmarza4,5,6,7,8,9
1Servicio de Bioquímica Clínica y Patología Molecular, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain.
International journal of molecular sciences
|January 28, 2026
概括
氧化应激通过破坏细胞和组织驱动血管疾病. 个性化抗氧化疗法和验证的生物标志物对于有效预防和治疗心血管疾病至关重要.
科学领域:
- 心血管研究研究心血管研究
- 氧化压力生物学 氧化压力生物学
- 生物标志物开发 生物标志物开发
背景情况:
- 氧化应激 (OS),反应性氧物种 (ROS) 和抗氧化防御之间的不平衡,是动脉样硬化和高血压等血管病理的核心.
- 来自NADPH氧化酶和线粒体等来源的ROS诱导内皮功能障碍,促进光滑肌肉的增殖和动脉生成.
研究的目的:
- 审查将OS与血管损伤联系起来的分子机制.
- 批判性地评估将OS生物标志物转化为临床实践的挑战.
- 探索针对血管疾病的个性化抗氧化剂治疗的新兴趋势.
主要方法:
- 系统审查有关氧化应激和血管疾病的文献.
- 分析涉及ROS介导血管损伤的分子通路.
- 评估当前和新兴的氧化应激生物标志物.
- 评估针对氧化应激的治疗策略.
主要成果:
- 氧化应激显著导致内皮功能障碍,脂质氧化,亡和血管疾病中的炎症.
- 对OS的生物标志物,包括抗氧化酶活性和氧化损伤产品,显示出临床潜力,但需要标准化和验证.
- 目前针对OS的治疗策略产生了不一致的临床结果,突出了针对性方法的需要.
结论:
- 氧化应激是血管病理的一个关键媒介,需要在生物标志物验证和向治疗方面取得进展.
- 开发针对特定ROS源 (例如NOX抑制剂) 的精确疗法和基于氧化还原分析的个性化治疗方法对于有效的心血管疾病管理至关重要.
- 将当前知识转化为临床实践需要强大的生物标志物标准化和验证,以改善心血管疾病的预防,诊断和治疗.
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