超越基因组:表观遗传学可以预测在格雷夫斯病和甲状腺眼病中的治疗成功吗?
Jacopo Manso1, Dario Sardone2, Vincenzo Marotta3
1Endocrinology Unit, Oncology Area Department, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy.
International journal of molecular sciences
|January 28, 2026
概括
像DNA甲基化和microRNAs这样的表观遗传生物标志物显示出预测格雷夫斯病和甲状腺眼病治疗反应的前景. 这些标记物可以帮助个性化治疗自身免疫性甲状腺疾病.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 格雷夫斯病 (GD) 和甲状腺眼病 (TED) 是自身免疫性疾病,治疗反应不同.
- 在抗甲状腺药物 (ATD) 停用后,高达50%的GD患者复发,而20-50%的TED患者对葡萄糖皮质激素 (GC) 治疗有抗性.
研究的目的:
- 在GD和TED中审查表观遗传修饰作为个性化治疗的预测生物标志物.
- 专注于DNA甲基化和microRNAs (miRNAs) 来预测治疗结果.
主要方法:
- 从PubMed.com系统审查最近的研究结果 (到2025年).
- 对研究DNA甲基化和miRNA特征与治疗反应相关的研究进行分析.
主要成果:
- 对于GD,T细胞中Th17相关基因的低甲基化表明ATD复发风险.
- 循环中的miRNAs (miR-346,miR-23b-5p,miR-92a-3p) 可能预测GD缓解.
- 对于TED,特定的miRNA预测了GC敏感性:高的miR-146a表明了积极的反应,低的miR-224-5p表明了不响应.
结论:
- 表观遗传生物标志物,特别是miRNAs,为分层患者和优化Graves自身免疫治疗提供了潜力.
- 关于生物疗法的基因组修饰和表观遗传预测因子存在研究缺口.
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