含有大麻素的粘膜粘合剂PLGA纳米球-花色素水凝贴片用于口腔治疗应用
Badmaarag-Altai Chuluunbaatar1,2, Jisu Park1, Junyoung Song1
1School of Pharmacy, Jeonbuk National University, Jeonju 54896, Republic of Korea.
International journal of molecular sciences
|January 28, 2026
概括
这项研究开发了一种装载着大麻 (CBD) 纳米球的新型酸盐水凝. 该配方显示了增强的粘膜粘合,持续释放和强大的抗炎和抗菌作用,为治疗牙周疾病提供了潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药理学 药理学 是一个学科.
- 口腔健康研究研究 口腔健康研究
背景情况:
- 大麻二醇 (CBD) 显示出治疗疼痛和炎症的治疗潜力.
- 目前的局限性包括CBD的溶解性差和粘膜透性.
- 牙周炎症的机制需要进一步研究.
研究的目的:
- 开发和描述一种基于基托桑的粘膜水凝,其中包含含有CBD的PLGA纳米球 (CPN水凝).
- 为了评估CPN水凝的物理化学特性,药物释放和透性.
- 评估CPN水凝对口腔疾病的抗炎,抗氧化,抗菌和伤口愈合潜力.
主要方法:
- 物理化学表征 (FT-IR,SEM,颗粒大小,风病学,胀,扩散).
- 使用弗朗茨细胞进行体外透性研究.
- 生物评估包括抗氧化剂 (DPPH测试),抗菌 (金黄色葡萄球菌),伤口愈合和抗炎症 (IL-6,TNF-α的RT-qPCR) 测试.
主要成果:
- 该CPN水凝表现出均的结构,提高粘性弹性和持续的CBD释放 (>90%在96小时).
- 观察到增强的粘膜透性 (124.1μg/cm2 72小时后) 和显著增加的粘膜粘合.
- 已证明具有强大的抗氧化剂 (73.65% DPPH 清除),抗菌 (>99% S. aureus 抑制),伤口愈合和抗炎作用 (降低IL-6和TNF-α的调节).
结论:
- 开发的CPN加载的奇托水凝提供了延长的粘膜保留,持续的CBD释放和强大的生物活性.
- 这种配方显示出作为针对性治疗剂的显著潜力,用于炎症性口腔疾病,如牙炎和牙周炎.
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