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微环境调节乳腺癌细胞的瘤起源性,这取决于激素受体状态

Priscila Pagnotta^1,2, Tomás González-Garello³, María Luján Crosbie⁴

¹Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires 1428, Argentina.

International journal of molecular sciences

|January 28, 2026

概括

乳腺癌的进展受脂肪组织的影响. 靠近瘤会改变脂肪细胞,释放影响乳腺癌细胞行为的因素,根据亚型不同.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
生物化学生物化学

背景情况:

脂肪组织是瘤微环境的组成部分,影响乳腺癌 (BC) 的进展.
靠近瘤可以改变脂肪组织的特征和功能.

研究的目的:

为了研究瘤的接近如何改变脂肪组织标记物.
评估脂肪组织衍生的可溶性因子对乳腺癌细胞瘤发生性的影响.

主要方法:

来自BC患者和健康捐赠者的脂肪组织实验的分析,根据瘤的近距离分类 (相邻,遥远,正常).
评估与脂肪相关的和与预后相关的标记物 (例如,FABP4,维门丁,卡韦奥林-1,CD44,MMP9,阿迪波内克丁).
从激素受体阳性 (HR+BC) 和三阴性乳腺癌 (TNBC) 细胞系上的实验物中评估条件介质 (CM).

主要成果:

在瘤附近,FABP4和维门丁的表达增加;其他标记物显示微小的变化.
来自相邻的扩展体的CM促进了T47D (HR+BC) 细胞的迁移,细胞骨变化和减少粘附.
CM对TNBC细胞 (MDA-MB-231) 的影响不同,相邻的CM增加了MMP9,两种CM类型都部分诱导了类似上皮的状态.

结论:

瘤附近的脂肪组织表现出改变的标记物表达.
脂肪组织分泌的可溶性因子显著影响乳腺癌细胞的行为.
这些影响取决于乳腺癌亚型 (HR+BC与TNBC).

关键词:

激素受体激素受体激素受体人类乳腺脂肪组织脂肪组织瘤微环境是一个微环境.瘤发生的起源

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