制备和体外生物活性评估Ganoderma lucidum黑色素稳定纳米颗粒
Ruru Liu1, Qunluo Cao1, Heng Miao1
1College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Foods (Basel, Switzerland)
|January 28, 2026
概括
黑色素稳定纳米颗粒 (GLM-SeNPs) 显示出增强的稳定性和抗炎性质. 这些新型纳米颗粒还可以抑制食物传播的病原体,这表明功能性食品和保存的潜力.
科学领域:
- 纳米技术 纳米技术
- 食品科学 食品科学 食品科学
- 生物材料是一种生物材料.
背景情况:
- 纳米粒子 (SeNPs) 是有前途的食品添加剂,但缺乏稳定性和生物安全性.
- 光黑素 (GLM) 被探索为SeNPs的天然稳定剂.
- 目前的限制阻碍了SeNP在食品行业的应用.
研究的目的:
- 综合和描述GLM稳定SeNPs (GLM-SeNPs) 的方法.
- 评估GLM-SeNPs的抗炎和抗微生物特性.
- 探索GLM-SeNPs作为功能性食品成分的潜力.
主要方法:
- 合成GLM-SeNPs使用亚酸减少.
- 纳米粒子大小,分散性和含量的表征.
- 在体外评估对LPS诱导的巨细胞的抗炎作用.
- 对抗食物传播病原体的抗微生物活性的评估.
主要成果:
- 均大小 (55-75 nm) 和分散良好的GLM-SeNP已成功合成.
- S-GLM变种显示出最高的含量和优越的稳定性.
- 通过抑制NF-κB通路,GLM-SeNPs通过调节细胞因子表达 (降低TNF-α,IL-6,IL-1β;上调IL-10) 显示出显著的抗炎作用.
- GLM-SeNPs对常见的食源性病原体表现出强大的抑制作用.
结论:
- GLM有效地稳定了SeNPs,改善了它们在食品应用中的性能.
- GLM-SeNPs具有显著的抗炎和抗菌活性.
- GLM-SeNPs代表了在功能性食品和保存中高价值自然化合物的利用的新策略.
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