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不同类型的乳杆菌 (Lactobacillus helveticus) 对免疫缺陷小鼠免疫功能的作用
Shunyu Wang1,2,3, Hongchao Wang1,2, Fuhao Li1,2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Foods (Basel, Switzerland)
|January 28, 2026
概括
来自Lactobacillus helveticus的富含曼诺和富可的外聚糖可促进免疫功能. 这些化合物在免疫缺陷小鼠模型中恢复了免疫器官健康和肠道微生物群平衡.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 免疫缺陷在癌症治疗和移植方面带来了挑战.
- 目前的治疗方法有局限性和副作用.
- 乳杆菌外聚糖 (EPS) 显示出与单糖组成相关的免疫调节潜力.
研究的目的:
- 为了研究从Lactobacillus helveticus中提取的富含曼诺斯和富可斯的EPS的免疫调节作用.
- 为了评估它们在循环胺 (CTX) 诱导的免疫缺陷小鼠模型中的疗效.
主要方法:
- 建立了一个CTX诱导的免疫缺陷小鼠模型.
- 施用了富含曼诺斯和富含福可斯的 Lactobacillus helveticus EPS.
- 评估免疫器官指数,细胞因子概况,组织病理学和肠道微生物群.
主要成果:
- EPS显著增加了脏指数,并减少了白色脉缩小.
- 通过EPS恢复了细胞因子稳定和减轻了肝硬化.
- EPS重组了肠道微生物群,增加了多样性和有益的细菌,如Firmicutes,Bacteroides,Faecalibacterium和Bifidobacterium.
结论:
- 富含曼诺和富可的EPS通过多种机制减轻CTX诱导的免疫缺陷.
- 这些EPS恢复免疫器官的完整性,调节细胞因子,并恢复肠道微生物群的稳定性.
- 提供了免疫调节功能性食品的基础,并对微生物群-免疫轴的洞察力.
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