乳酸菌 (Lacticaseibacillus rhamnosus) CU262通过肠肝轴重编程减轻高脂肪饮食引起的肥胖症
Hezixian Guo1, Liyi Pan1, Linhao Wang1
1College of Food Science, South China Agriculture University, Guangzhou 510642, China.
Foods (Basel, Switzerland)
|January 28, 2026
概括
乳酸菌cillus rhamnosus CU262 益生菌通过改善肠道微生物群,减少炎症和正常化高脂肪饮食小鼠的脂质新陈代谢,有效地对抗肥胖.
科学领域:
- 微生物学 微生物学
- 代谢健康 代谢健康
- 肠 - 肝研究轴研究
背景情况:
- 肥胖与肠道失调症,脂质失调症和肝损伤有关.
- 肠肝轴在新陈代谢平衡中起着至关重要的作用.
- 准肠道微生物群为肥胖管理提供了一个潜在的战略.
研究的目的:
- 为了评估Lacticaseibacillus rhamnosus CU262.26的抗肥胖作用.
- 通过多学科的方法阐明潜在的机制.
- 评估对肠道微生物群,宿主新陈代谢和肝功能的影响.
主要方法:
- 使用了一种高脂肪饮食 (HFD) 的小鼠模型.
- 小鼠在12周内补充了L. rhamnosus CU262的药物.
- 进行了表型,血清/肝脏生物化学,16S rRNA测序,便SCFA和RNA-seq的综合分析.
主要成果:
- CU262显著降低了体重增加,脂肪,并改善了脂质特征 (TC,TG,LDL-C,HDL-C).
- 它降低了肝酶 (ALT/AST),减少了炎症 (IL-6,TNF-α),并减轻了氧化应激.
- CU262调节了肠道微生物群的组成,增加了有益细菌 (Akkermansia),并促进了SCFA生产 (乙酸盐,丁酸盐).
- 肝转录学揭示了HFD诱导的胆固醇生物合成和ER压力的逆转,与增强的氧化酸化和谷氨代谢.
结论:
- 在HFD小鼠模型中,Lacticaseibacillus rhamnosus CU262在HFD小鼠模型中显示出显著的抗肥胖作用.
- 益生菌通过重新编程肠道微生物群-SCFA-肝脏基因网络沿着肠肝轴而起作用.
- CU262显示出作为一种功能性益生菌的潜力,用于控制肥胖和相关代谢障碍.
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