调查Juglans regia新鲜水果提取物的抗炎活性
Lorenza Marinaccio1, Eleonora Procino2, Giulia Gentile2
1Department of Innovative Technologies in Medicine and Dentistry, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Foods (Basel, Switzerland)
|January 28, 2026
概括
A Juglans regia L.新鲜水果提取物在体内表现出显著的抗炎作用,特别是在减少热过敏和疼痛反应方面. 这种提取物显示出管理炎症的潜力,这是与前列腺癌发展有关的因素.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 在瘤学瘤学.
背景情况:
- 炎症越来越被认为是前列腺癌发展和进展的重要因素.
- Juglans regia L. (胡桃) 新鲜水果提取物已在体外证明对前列腺癌细胞具有抗氧化和抗增殖作用.
研究的目的:
- 在急性和慢性炎症模型中评估Juglans regia L.新鲜水果提取物的体内抗炎潜力.
- 通过使用in silico方法来研究基底在提取物抗炎活性的分子机制.
主要方法:
- 在体内评估抗炎活性使用zymosan诱导的胀,zymosan诱导的热过敏症和甲素试验.
- 在基分子对接研究中,预测与关键酶 (AChE,BChE) 和受体 (葡萄糖皮质体受体) 的相互作用.
- 使用二极管阵列检测 (HPLC-DAD) 的高性能液体染色学量化关键化合物 (素,酸).
主要成果:
- 提取物显著减少了热过敏症和甲素诱导的时间,这表明它具有抗nociceptive和抗炎作用.
- 在分析显示,素与乙胆化酶 (AChE) 以及酸与葡萄糖皮质体受体具有强烈的结合亲和力.
- 在提取物中量化了奎思丁和酸,分别为0.246 ± 0.003 mg/g和0.036 ± 0.004 mg/g.
结论:
- Juglans regia L. 新鲜水果提取物具有显著的体内抗炎和抗鼻性质.
- 提取物的治疗潜力可能归因于诸如奎尔素和酸等化合物,这些化合物向炎症途径.
- 进一步的研究是有必要的,以探索提取物在管理炎症相关疾病,包括前列腺癌的作用.
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