后生菌对抗多药耐药性大肠杆菌的抗菌作用
Çiğdem Sezer1, Nebahat Bilge1, Gönül Damla Büyük1
1Department of Food Safety and Public Health, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Türkiye.
Foods (Basel, Switzerland)
|January 28, 2026
概括
来自开的细菌的后生物体对在中发现的抗生素耐药性大肠杆菌产生强大的抗菌作用. 乳植物细菌 (Lactiplantibacillus plantarum) 后生菌对产生ESBL的大肠杆菌表现出杀死和抑制生长的作用.
科学领域:
- 微生物学 微生物学
- 食品安全 食品安全
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 抗生素耐药的病原体,如产生扩展谱β-乳糖酶 (ESBL) 的大肠杆菌,是严重的公共卫生威胁,特别是在食品感染中.
- 经常在家禽中发现产生ESBL的大肠杆菌,由于不受管制的抗生素使用和卫生条件不佳等因素,造成风险.
- 多药耐药细菌的出现需要探索新型抗菌剂,如后生物药.
研究的目的:
- 评估来自开衍生物的 Lactiplantibacillus plantarum 和 Lactococcus lactis 的后生菌对ESBL阳性大肠杆菌的抗菌疗效.
- 确定这些后生物质的最小抑制度 (MIC) 和最小杀菌度 (MBC).
主要方法:
- 从原肉样本中分离和识别大肠杆菌.
- 使用磁盘扩散和双磁盘协同试验确定抗菌素耐药性概况和ESBL阳性.
- 通过宏稀释方法评估后生物抗菌活性,以找到MIC和MBC值.
主要成果:
- 在48%的生肉样本中检测到ESBL阳性大肠杆菌.
- 从18磅开始的后生物. 脚部和20个Lc. 乳糖菌株对ESBL阳性大肠杆菌表现出显著的抗菌活性.
- 一个英. 脚部后生物体显示出细菌静止和杀菌效应,而LC. 乳糖后生物只表现出细菌静止作用.
结论:
- 来自 Lb. 的后生物. 脚部和Lc. 的位置. 乳制品对在肉中发现的ESBL阳性大肠杆菌有效.
- 一个英. 与Lc.相比,足部后生菌表现出更强的抗菌作用,包括杀菌作用. 乳糖后生物. 乳糖后生物.
- 这些发现凸显了后生物的潜力,后生物作为负担得起的,耐热稳定的,有效的替代传统抗生素,以对抗食源性病原体.
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