患有唐氏综合征的儿童甲状腺功能障碍的患病率,频谱和管理:沙特阿拉伯南部的一项回顾性研究
Youssef Ali Alqahtani1, Ayed A Shati1, Ayoub Ali Alshaikh2
1Department of Child Health, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia.
Children (Basel, Switzerland)
|January 28, 2026
概括
甲状腺功能障碍影响了沙特阿拉伯超过一半的唐氏综合征 (DS) 儿童,亚临床和自身免疫性甲状腺功能低下是最常见的. 尽管查率很高,但改善治疗管理至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 遗传学和遗传性疾病
- 公共卫生 公共卫生
背景情况:
- 唐氏综合征 (DS) 与甲状腺功能障碍的高发病率有关.
- 国际指导方针提倡对DS患者进行定期查.
- 这项研究调查了沙特阿拉伯儿童的甲状腺功能障碍.
研究的目的:
- 为了确定患有唐氏综合征的儿童甲状腺功能障碍的患病率和频谱.
- 为了评估甲状腺功能障碍在这个人群中的管理结果.
- 确定与DS中甲状腺功能障碍相关的风险因素和症状负担.
主要方法:
- 对106名患有DS的儿童进行了回顾性横截面研究.
- 从沙特两个医疗保健中心的医疗记录中收集的数据.
- 分析包括人口统计,甲状腺功能,自身免疫状态,治疗和随访.
主要成果:
- 在DS的儿童中,甲状腺功能障碍的患病率为52.8%.
- 亚临床甲状腺功能低下症 (46.4%) 和自身免疫性甲状腺功能低下症 (30.4%) 是最常见的.
- 甲状腺疾病的家族病史是一个显著的风险因素 (aOR=4.57).
结论:
- 甲状腺功能障碍在沙特南部的儿童中非常普遍.
- 亚临床和自身免疫性甲状腺功能低下症是主要的类型.
- 尽管查遵守良好,但治疗优化和长期管理需要改进.
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