行为和认知评估在一系列的术语中 - - 对于孕期儿童来说很小
Rossella Vitale1, Annachiara Libraro2, Francesca Cocciolo1
1Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", 70124 Bari, Italy.
Children (Basel, Switzerland)
|January 28, 2026
概括
对于妊娠年龄 (SGA) 来说,出生小的儿童比同龄人表现出较低的智商分数和更多的内化行为. 出生的头周长预测了认知功能,但生长激素治疗在本研究中没有显示出认知益处.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经发育儿科 神经发育儿科
- 儿童心理学 儿童心理学
背景情况:
- 对于妊娠年龄 (SGA) 来说出生小的儿童面临风险,包括生长障碍和神经发育问题.
- 关于SGA儿童认知和行为结果的现有研究是不一致的.
- 关于复合人体生长激素 (rhGH) 治疗对SGA儿童认知发育的影响的数据有限.
研究的目的:
- 为了比较术期SGA儿童的认知表现和情绪-行为功能,与适合妊娠年龄 (AGA) 的同龄人相比.
- 确定SGA儿童中神经认知结果的新生儿预测因素.
- 为了探索 rhGH 治疗和未治疗 SGA 儿童之间的认知结果差异.
主要方法:
- 18名期末SGA儿童和23名AGA对照接受了认知测试 (WISC-IV) 和行为评估 (CBCL).
- 进行了人类测量和生化评估.
- 出生测量 (体重,长度,头周长) 被分析为认知预测指标.
主要成果:
- SGA儿童的智商得分明显较低,特别是在感知推理 (PRI) 和处理速度 (PSI) 中,口头理解和工作记忆被保留.
- SGA儿童表现出更多的内化行为,但外化行为与对照行为相似.
- 较小的出生头周长预测了较低的PRI和PSI得分; rhGH治疗与认知结果无关.
结论:
- 与AGA同龄人相比,长期SGA儿童表现出明显的认知缺陷和行为模式.
- 出生的头周长是SGA儿童特定认知功能的重要预测指标.
- 需要进一步的纵向研究,以了解生长限制对大脑发育的影响以及GH治疗的作用.
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