当丸激素衰退时:由环境毒素,代谢功能障碍和丸的交叉声调形成的莱迪格细胞衰老
Aris Kaltsas1, Fotios Dimitriadis2, Athanasios Zachariou3
1Third Department of Urology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Cells
|January 28, 2026
概括
莱迪格细胞功能下降会损害男性生育能力,并与衰老和环境因素有关. 减轻压力,优化新陈代谢和向炎症的策略可以保护雄激素生产和生殖健康.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 细胞生物学 细胞生物学
- 毒理学 毒理学 毒理学
背景情况:
- 莱迪格细胞类固醇生成的下降有助于晚期出现的阴性双胞胎症和男性生殖健康受损.
- 除了慢性衰老之外的因素,包括环境和代谢压力因素,影响莱迪格细胞功能.
研究的目的:
- 审查和综合证据,关于细胞和分子机制危害莱迪格细胞功能和丸的证据.
- 整合关于环境内分泌干扰化学物质 (EDC),肥胖,代谢功能障碍和丸衰老的发现.
主要方法:
- 来自各种模型系统的实验和转化证据的审查.
- 整合了强调氧化应激,ER应激,线粒体功能障碍,亡,自和衰老的数据.
- 使用单细胞转录基因图谱来解决莱迪格细胞异质性和细胞-细胞通信.
主要成果:
- 暴露于有毒物质和代谢压力汇聚在受损的器官质量控制和氧化还原信号上,导致降低类固醇生成能力和潜在的Leydig细胞过早衰老.
- 丸衰老通过炎症和生物力学改造改变了微环境,可能会影响莱迪格细胞稳态和再生.
- 单细胞转录组学揭示了莱迪格细胞异质性和与其他丸细胞的年龄相关的通信变化.
结论:
- 机械洞察力提供了保护雄激素生产和生育能力的机会.
- 策略包括暴露缓解,代谢优化,保持生育的内分泌刺激,以及针对炎症,衰老和再生.
- 需要在人体组织和队列中进一步验证,才能充分转化研究结果.
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