西方饮食抑制T调控细胞功能,以在代谢功能障碍相关的脂肪性肝病中促进肝炎
Sudrishti Chaudhary1,2, Ravi Rai1,3, Pabitra B Pal1,4
1Pittsburgh Liver Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
调节性T细胞 (Tregs) 在代谢功能障碍相关的脂肪性肝病 (MASLD) 期间在肝脏中积累,但它们的功能受到肝脏微环境的影响,导致炎症和纤维化恶化.
科学领域:
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 调节性T细胞 (Tregs) 对于免疫恒温至关重要.
- 它们在代谢功能障碍相关的脂肪性肝病 (MASLD) 中的作用尚未完全理解.
- MASLD的特点是肝脏肥胖症,炎症和纤维化.
研究的目的:
- 调查Tregs在MASLD中的作用和功能.
- 确定肝脏微环境如何影响MASLD中的Treg功能.
- 探索调节Treg数在MASLD中的治疗潜力.
主要方法:
- 西式饮食 (WD) 在小鼠养中诱导MASLD.
- 分析肝脏内免疫细胞,包括Tregs,中性粒细胞和巨细胞.
- 特雷格耗尽和特雷格诱导模型.
- 对Treg免疫抑制能力的ex vivo功能测定.
主要成果:
- 在WD养小鼠和MASH患者中观察到肝脏内Tregs和T细胞效应者的增加.
- 缺少或耗尽Tregs加剧了WD诱导的肝炎和纤维化.
- 诱导Tregs改善了肝脏肥胖症,炎症和纤维化.
- 来自WD养小鼠的肝内Tregs显示免疫抑制功能受损,受葡萄糖和棕酸盐的影响.
结论:
- 在MASLD中的肝脏微环境会损害Treg功能.
- 损坏的Tregs无法抑制效应免疫细胞,使炎症和纤维化延续.
- 调节Treg数或功能可能为MASLD提供治疗策略.
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