Nicholas S Tolwinski1, Sheng Fong2,3, Sujithra Shankar1

  • 1Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.

Cells
|January 28, 2026
PubMed
概括

细胞衰老涉及功能下降,衰老细胞和干细胞耗尽. 使用Yamanaka因子逆转细胞可塑性显示出延长寿命和改善健康寿命的前景.

相关概念视频

Osmoregulation in Insects01:47

Osmoregulation in Insects

Malpighian tubules are specialized structures found in the digestive systems of many arthropods, including most insects, that handle excretion and osmoregulation. The tubules are typically arranged in pairs and have a convoluted structure that increases their surface area.
17.6K
What is Conservation Biology?01:57

What is Conservation Biology?

Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.3K
Conservation of Small Populations02:04

Conservation of Small Populations

Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.1K
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.1K
Partial Fractions01:28

Partial Fractions

A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...
215
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.4K