PD-L1和BAP1作为恶性多层甲状腺瘤的预后生物标志物
Milija Gajić1, Vesna Ćeriman Krstić1,2, Natalija Samardžić1
1Clinic for Pulmonology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Cells
|January 28, 2026
概括
评价PD-L1和BAP1表达作为恶性多叶膜间皮瘤 (MPM) 的预后生物标志物. 虽然对整体存活率没有统计学意义,但PD-L1阳性和BAP1损失与MPM患者的结果更差有关.
科学领域:
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
- 胸部外科手术 胸部外科手术
背景情况:
- 恶性膜间皮瘤 (MPM) 是一种侵袭性的胸部恶性瘤.
- 在MPM中,PD-L1和BAP1被研究为潜在的预后生物标志物.
- 之前的研究对其预后价值产生了相互矛盾的结果.
研究的目的:
- 为了追溯分析PD-L1和BAP1表达在MPM患者的预后意义.
- 为了将PD-L1和BAP1表达与整体存活率 (OS) 和无进展存活率 (PFS) 相关联.
主要方法:
- 对53名MPM患者的回顾性分析.
- 通过免疫组织化学评估PD-L1表达 (≥1%和≥10%) 和BAP1损失.
- 与OS和PFS的统计相关性.
主要成果:
- 在39.6%的患者中观察到PD-L1表达 (≥1%);在81.1%的患者中观察到BAP1损失.
- 平均生存期为11个月. MPM亚型,早期阶段,治疗和良好表现状态 (PS) 与更好的生存率有关.
- 虽然PD-L1和BAP1表达没有达到OS的统计学意义,但趋势表明PD-L1≥10%的生存率更差,而BAP1损失的生存率更好.
- 在PD-L1≥1%和BAP1损失的情况下,PFS数量较长,但在PD-L1≥1%和BAP1阳性 (p=0.048) 情况下,PFS显著较短.
结论:
- PD-L1和BAP1没有显示出作为MPM整体存活时间的预后生物标志物的统计学意义.
- 然而,积极的PD-L1表达和BAP1损失在数值上与MPM患者的生存结果较差有关.
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