单细胞测序揭示了动物骨肌肉发育中的MuSCs和FAPs之间的交叉声
Yuan Chen1, Yiming Gong1, Xiaoli Xu1
1Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
这项研究使用单细胞RNA测序绘制了山羊骨肌肉发育的地图. 它揭示了独特的细胞群和肌肉干细胞和祖先之间的共同调节途径,提供了对反动物肌肉发育的见解.
科学领域:
- 发展生物学 发展生物学
- 细胞和分子生物学 细胞和分子生物学
- 进行比较基因组学.
背景情况:
- 骨肌肉的发育和衰老是复杂的过程.
- 控制山羊骨肌肉的细胞机制尚不清楚.
- 需要一个关于山羊肌肉发育的全面地图.
研究的目的:
- 创建第一个单细胞RNA测序 (scRNA-seq) 的山羊长极背肌的图谱.
- 在肌肉发育过程中识别和表征不同的细胞亚群.
- 探索细胞与细胞的相互作用和调节网络在发展山羊肌肉.
主要方法:
- 单细胞RNA测序 (scRNA-seq) 的120,944个细胞.
- 对14个发育阶段的分析 (胚胎30日到11年出生后).
- 肌肉卫星细胞 (MuSCs) 和纤维基原生细胞 (FAPs) 亚种群的识别.
主要成果:
- 标志着独特的早期胚胎发育 MuSCs_ACT1_high 和与衰老相关的 MuSCs_CDKN1A_high 亚群.
- 确定了早期的FAPs_MDFI_高,具有基和纤维基分化潜力.
- 揭示了 MuSC 和 FAP 之间共享的转录因子配置文件,表明了共同的发育信号通路.
- 发现DLK1-NOTCH3连体-受体对在维护FAPs的MuSC静止中的作用.
结论:
- 该scRNA-seq图谱为反动物骨肌肉发育提供了基础资源.
- 共同的监管机制管理着 MuSC 和 FAP 的发展.
- DLK1-NOTCH3通路对于山羊的早期肌肉干细胞调节至关重要.
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