早期营养模式和与ROP严重程度相关的代谢生物标志物
Laura Bujoreanu Bezman1,2, Carmen Tiutiuca2,3, Florin Ciprian Bujoreanu2
1Department of Ophthalmology, "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania.
Medicina (Kaunas, Lithuania)
|January 28, 2026
概括
早期的肠道养和自然养可以防止早产性视网膜病变 (ROP) 的进展. 像肝脏,脏和葡萄糖水平这样的代谢标志物与早产婴儿的ROP严重程度相关.
科学领域:
- 新生儿科学 新生儿科学
- 眼科医生 眼科 眼科
- 儿童营养学 儿童营养学
背景情况:
- 早产视网膜病变 (ROP) 是可预防的儿童失明的主要原因.
- ROP的严重程度与早产儿的营养,新陈代谢和系统因素有关.
研究的目的:
- 评估早期营养和代谢参数与ROP严重性之间的关联.
- 为了确定在早产婴儿中ROP进展的潜在预测因素.
主要方法:
- 140名早产婴儿 (280只眼睛) 的回顾性研究,使用国际早产视网膜病变分类 (ICROP) 标准.
- 收集了28天内养 (肠道,亲肠道,自然) 持续时间和血清生物标志物 (ALT,AST,总蛋白质,葡萄糖,尿素,肌) 的数据.
- 使用克鲁斯卡尔-瓦利斯和奇方测试 (p < 0.05) 的统计分析.
主要成果:
- 在53.57%的婴儿中观察到ROP;较早的肠道养与较不严重的ROP相关.
- 延迟营养和长时间的肠外营养与先进的ROP阶段有关.
- 严重的ROP与AST,ALT,尿素,肌素和较低总蛋白质的升高有关;在2-3阶段观察到的血糖不稳定性.
结论:
- 早期的肠道和自然养显示出对ROP进展的保护作用.
- 肝脏,脏和血糖参数与ROP严重程度相关,反映了婴儿的脆弱性.
- 将营养和代谢评估纳入常规查可以改善ROP风险的识别和监测.
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