整合贝叶斯推理和机器学习来评估TAP和素-2作为急性胰腺炎系统性炎症的早期生物标志物
Alina Calin Frij1,2, Cristian Velicescu1,2, Andrei Andone1
1Department of Surgery, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Medicina (Kaunas, Lithuania)
|January 28, 2026
概括
早期尿素-2显示为预测急性胰腺炎严重程度的生物标志物具有前途. 这项研究确定了不同的患者表型和改善炎症负担评估的潜力.
科学领域:
- 生物化学 生物化学
- 临床诊断 临床诊断 临床诊断
- 生物标志物发现发现
背景情况:
- 预测急性胰腺炎 (AP) 严重程度仍然具有挑战性.
- 素激活 (TAP) 和素-2可能比传统标记物提供更早的病理生理洞察力.
研究的目的:
- 评估血清和尿液TAP和素-2作为AP的早期生物标志物.
- 研究这些生物标志物,炎症和临床因素之间的关系.
- 通过集群和机器学习来识别不同的AP患者表型.
主要方法:
- 54名AP患者的回顾性队列分析.
- 测量24小时血清和尿液TAP和素-2.
- 贝叶斯相关性,调解分析,K-means集群,弹性网和随机森林机器学习的应用.
主要成果:
- 血清TAP与CRP和年龄相关;尿素-2与氨酶相关.
- TAP和素-2解释了CRP对胰腺酶升高的影响的42-44%.
- 确定了三个患者子组:"轻度激活"",中度系统"和"严重的胰腺-脏".
- 尿素-2和年龄是炎症的关键预测因素 (随机森林R2=0.53).
结论:
- 与血清标志物相比,尿二是AP系统性炎症强度的优越早期预测剂.
- 这些生物标志物有助于评估蛋白质分解功能障碍,清除和炎症负担.
- 综合性分析揭示了独特的AP表型,有助于早期评估和潜在的精确诊断.
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